腫瘍内科

書籍

学会発表（国内学会）

2023年度

2023.07 第30回日本遺伝子診療学会大会、第8回クリニカルバイオバンク学会シンポジウム合同学術集会

• がん遺伝子パネル検査の解析成功率の向上を目的とした後方視的解析
  井本 清美, 大池 信之, 小池 淳樹, 柳澤 信之, 野呂瀬 朋子, 大川 千絵, 島田 直樹, 新井 裕之, 武田 弘幸, 山本博幸, 若松 宏武, 佐藤 知雄, 砂川 優, 山野 嘉久.

2022年度

2022.04 DCT産学連携勉強会

• 遠隔医療を用いた治験プレスクリーニング検査の実装
  砂川優

2022.06 第7回がんサポーティブケア学会学術集会

• がんの日常診療におけるePROによる症状モニタリングの有用性の評価および、有害事象とQoLの実態に関するレジストリ研究（RegiPRO study）
  堀江良樹, 宮路天平, 土井綾子, 川口崇, 小倉孝氏, 兼安貴子, 長島文夫, 中島貴子, 山口拓洋
• 切除可能大腸がん高齢患者の高齢者機能評価と臨床経過
  宇井一眞、土井綾子、武田弘幸、梅本久美子、新井裕之、堀江良樹、水上拓郎、伊澤直樹、小倉孝氏、砂川優

2022.09 CRCと臨床試験のあり方を考える会議

• 臨床試験における遠隔同意について考える
  内山修太朗, 原直也, 川名部新, 中川朋子, 中村祐太, 月山秀一, 水上拓郎, 曽根正勝

2022.09 第23回日本内分泌学会関東甲信越支部学術集会

• 食道癌に対してニボルマブ治療開始13か月後、尿糖自己測定によりirAEによる劇症1型糖尿病を早期に捉えた1例
  内山修太朗, 原直也, 川名部新, 中川朋子, 中村祐太, 月山秀一, 水上拓郎, 曽根正勝

2022.09 第76回日本食道学会学術集会

• 食道扁平上皮癌・胃食道接合部癌におけるctDNAを用いた治療戦略
  Hiroyuki Takeda, Ayako Doi, Yoshiki Horie, Hiroyuki Arai, Kumiko Umemoto, Naoki Izawa, Takashi Ogura, Yu Sunakawa.

2022.10 第60回日本癌治療学会学術集会

• RAS野生型大腸癌における血管新生因子と2次治療FOLFIRI+RAMの効果:JACCRO CC-16AR
  砂川優, 安井久晃, 塩澤学, 武田弘幸, 赤澤直也, 佐川保, 白石和寛, 大北仁裕, 奥山浩之, 結城敏志, 谷中昭子, 阿部由紀子, 市川度, 藤井雅志, 辻晃仁.
• TRUSTY試験における血管新生関連遺伝子とFTD/TPI+BEVの有効性の検討
  渡邉 純, 久保木 恭利, 寺澤 哲志, 川上 尚人, 横田 満, 中村 将人, 小髙 雅人, 沖 英次, 砂川 優, 石原 聡一郎, 谷口 浩也, 中島 貴子, 森田 智視, 白尾 國昭, 吉野 孝之.
• RAS 野生型切除不能大腸癌における二次治療FOLFIRI＋ラムシルマブ療法の前治療レジメン別の効果：JACCRO CC-16サブ解析
  片岡 幸三, 辻 晃仁, 勝屋 弘雄, 藤田 正太郎, 弓削 浩太郎, 木藤 陽介, 福永 睦, 中村 将人, 佐川 保, 渡邉 貴紀, 塩澤 学, 砂川 優, 竹内 正弘, 市川 度, 藤井 雅志.
• RAS/BRAF野生型進行再発大腸癌患者における血中バイオマーカーのダイナミクスと抗EGFR抗体リチャレンジの有効性。REMARRY試験/PURSUIT試験
  太田 高志, 山崎 健太郎, 賀川 義規, 小谷 大輔, 坂東 英明, 加藤 健志, 沖 英次, 篠崎 英司, 砂川 優, 結城 敏志, 中島 裕理, 中村 能章, 若林 将史, 谷口 浩也, 吉野 孝之.
• リアルワールドデータ（RWD）から見た小腸癌のゲノムランドスケープ
  武田 弘幸, 山本 博之, 及川 律子, 梅本 久美子, 土井 綾子, 新井 裕之, 堀江 良樹, 久保田 洋平, 小倉 孝氏, 伊澤 直樹, Jay A Moore, Ethan Sokol, 砂川 優.
• 当院における抗EGFR抗体薬投与患者に対する診察前面談の取り組み
  横溝 綾子, 森田 一, 幕内 麻里, 湊川 紘子, 計良 貴之, 熱方 智和子, 堀江 良樹, 伊澤 直樹, 坂上 逸孝, 田中 恒明, 砂川 優.
• 進行胃癌・大腸癌における治療前の血中循環腫瘍DNA検出の臨床的妥当性
  青木 優, 中村 能章, 谷口 浩也, 小松 嘉人, 砂川 優, 塩澤 学, 太田 高志, 江崎 泰斗, 山﨑 健太郎, 佐竹 悠良, 松橋 延壽, 後藤 昌弘, 賀川 義規, 仁科 智裕, 吉野 孝之.

2023.02 第55回制癌剤適応研修会

• 初診時切除不能と判断したがConversion surgery後も長期生存している非乳頭部十二指腸癌の1例
  増田哲之, 小林慎二郎, 水上拓郎, 野呂瀬朋子, 梅澤早織, 井田圭亮, 土橋篤仁, 小泉哲, 砂川優, 大池信之, 大坪毅人
• 切除可能膵頭部癌に対するNAC-GSについての現況と課題
  小林慎二郎, 増田哲之, 梅本久美子, 梅澤早織, 井田圭亮, 土居綾子, 土橋篤仁, 小泉哲, 砂川優, 大坪毅人

2023.02 第95回日本胃癌学会学術集会

• 胃癌患者における免疫関連有害事象の予測因子としての自己免疫疾患関連抗体の臨床的意義
  Naoki Izawa, Hiroyuki Takeda, Yohei Kubota, Ayako Doi, Yoshiki Horie, Hiroyuki Arai, Kumiko Umemoto, Yu Sunakawa.
• Treatment for elderly gastric cancer patients -Geriatric assessment and clinical outcomes-
  Ayako Doi, Yohei Kubota, Hiroyuki Takeda, Kumiko Umemoto, Hiroyuki Arai, Yoshiki Horie, Naoki Izawa, Takashi Ogura, Yu Sunakawa.
• 胃がん患者における腸内細菌叢と臨床的特徴の検討：SCRUM-Japan MONSTAR-SCREEN
  澤田 憲太郎, 山下 理宇, 酒井 俊輔, 吉河 歩, 洞澤 智至, 中村 能章, 藤澤 孝夫, 門脇 重憲, 安井 久晃, 高橋 直樹, 町田 望, 牧山 明資, 後藤 昌弘, 砂川 優, 江﨑 泰斗, 山﨑 健太郎, 辻 晃仁, 吉野 孝之.
• 進行胃癌における腸内細菌関連バイオマーカー
  砂川 優.
• 高齢胃癌患者における高齢者機能評価と臨床経過
  土井 綾子, 久保田 洋平, 武田 弘幸, 梅本 久美子, 新井 裕之, 堀江 良樹, 伊澤 直樹, 小倉 孝氏, 砂川 優.
• 胃癌ゲノムプロファイリングによる druggable alteration の同定
  新井 裕之, 山本 博幸, 武田 弘幸, 久保田 洋平, 土井 綾子, 堀江 良樹, 梅本 久美子, 伊澤 直樹, 砂川 優.
• 胃癌患者における免疫関連有害事象の予測因子としての自己免疫疾患関連抗体の臨床的意義
  伊澤 直樹, 武田 弘幸, 久保田 洋平, 土井 綾子, 堀江 良樹, 新井 裕之, 梅本 久美子, 砂川 優.

2023.03 第20回日本臨床腫瘍学会学術集会

• RAS変異型切除不能進行・再発大腸癌患者における化学療法後のctDNA中RAS遺伝子変異ステータス：RASMEX study (JACCRO CC-17)
  伊澤　直樹, 松原 裕樹, 仁科 慎一, 塩澤 学, 傳田 忠道, 太田 博文, 根来 裕二, 田中 千弘, 川上 尚人, 松岡 宏, 田邊 裕貴, 池永 雅一, 奥田 博介, 石黒 敦, 賀川 義規, 佐竹 悠良, 砂川 優, 竹内 正弘, 市川 度, 藤井 雅志
• 切除不能なvulnerable大腸がん患者に関する実態調査：治療パターンと2次治療移行に関連する因子の検討
  伊澤　直樹, 木藤 陽介, 三谷 誠一郎, 日野 佳織, 川上 賢太郎, 花村 文康, 山本 祥之, 庄司 広和, 小森 梓, 朴 将源, 土橋 賢司, 馬場 英司, 加藤 恭子, 野長瀨 祥兼, 松本 俊彦, 古田 光寛, 川上 尚人
• A study to evaluate the clinical utility of stress data collection in cancer patients treated with chemotherapy
  Ayako Doi, Erika Horibe, Yohei Kubota, Hiroyuki Takeda, Kumiko Umemoto, Hiroyuki Arai, Yoshiki Horie, Naoki Izawa, Takashi Ogura, Kazumasa Tanzawa, Yasuyuki Kaga, Tomomi Shibuya , Satoshi Muta, and Yu Sunakawa.
• Efficacy and safety of fruquintinib in Japanese patients with refractory metastatic colorectal cancer from FRESCO-2
  Daisuke Kotani, Takayuki Yoshino, Toshiki Masuishi, Yu Sunakawa, Atsuo Takashima, Kentaro Yamazaki, Hisato Kawakami, Tomohiro Nishina, Yoshito Komatsu, Taito Esaki, Cathy Eng, Stacey Ukrainskyj, Rajash Pallai, Shivani Nanda, Zhao Yang, William Schelman, Marek Kania, Taroh Satoh.
• RAS野生型切除不能進行再発大腸癌に対する血中RAS変異と2次治療FOLFIRI+ramucirumab療法の効果: JACCRO CC-16AR
  安井 久晃, 松浦 正徒, 峯 孝志, 湯浅 康弘, 渡邉 貴紀, 金城 達也, 大北 仁裕, 奥山 浩之, 結城 敏志, 宮川 公毅, 小原 采奈, 市川 度, 藤井 雅志, 辻 晃仁.
• RAS野生型切除不能進行再発大腸癌に対するm-FOLFOXIRI+cetuximab vs. bevacizumabの生存解析: DEEPER試験(JACCRO CC-13)
  辻 晃仁, 遠藤 出, 小林 建司, 楠本 哲也, 湯浅 康弘, 三輪 啓介, 東風 貢, 佐川 保, 小髙 雅人, 久保田 祐太郎, 砂川 優, 関川 高志, 中村 将人, 市川 度, 藤井 雅志.
• がん薬物療法患者におけるストレスデータ収集の有用性に関する研究
  土井 綾子,,堀部 恵梨佳, 久保田 洋平, 武田 弘幸, 梅本 久美子, 新井 裕之, 堀江 良樹, 小倉 孝氏, 伊澤 直樹, 丹澤 和雅, 加賀 保行, 澁谷 朋実, 牟田 敏志, 砂川 優.
• 切除不能進行大腸癌におけるCDC37遺伝子発現のレゴラフェニブ療法の効果予測
  新井 裕之, 傳田 忠道, 久保田 洋平, 武田 弘幸, 土井 綾子, 堀江 良樹, 梅本 久美子, 伊澤 直樹, 砂川 優.
• RAS変異型切除不能進行・再発大腸癌患者における化学療法後のctDNA中RAS遺伝子変異ステータス：RASMEX study (JACCRO CC-17)
  伊澤 直樹, 松原 裕樹, 仁科 慎一, 塩澤 学, 傳田 忠道, 太田 博文, 根来 裕二, 田中 千弘, 川上 尚人, 松岡 宏, 田邊 裕貴, 池永 雅一, 奥田 博介, 石黒 敦, 賀川 義規, 佐竹 悠良, 砂川 優, 竹内 正弘, 市川 度, 藤井 雅志.
• 抗EGFR抗体薬併用化学療法進行再発大腸癌患者に対する2次治療FOLFIRI/ラムシルマブ併用療法の第II相試験：JACCRO CC-16 Update解析
  間中 大, 辻 晃仁, 澁谷 雅常, 石橋 敬一郎, 薮野 太一, 岡村 修, 古谷 卓三, 田中 千弘, 中村 将人, 佐川 保, 渡邉 貴紀, 塩澤 学, 砂川 優, 太田 博文, 小髙 雅人, 奥山 浩之, 大北 仁裕, 竹内 正弘, 市川 度, 藤井 雅志.
• 切除不能なvulnerable大腸がん患者に関する実態調査：治療パターンと2次治療以降に関連する因子の検討
  伊澤 直樹, 木藤陽介, 他.
• 切除不能なvulnerable大腸がん患者に関する実態調査：1次治療症例210例の検討
  日野佳織, 伊澤直樹, 木藤陽介, 他.
• 切除不能なvulnerable大腸がん患者に関する実態調査：2次治療症例の検討
  川上賢太郎, 伊澤直樹, 木藤陽介, 他.
• BRAF V600E変異型切除不能進行・再発大腸癌に対するFOLFOXIRI+/-Bevacizumab療法とDoublet療法の有効性及び安全性に関する後方視的検討
  中村真穂, 伊澤直樹, 下崎啓太郎, 他.
• 高齢者切除不能・再発胃癌に対するS-1単剤療法とS-1/L-OHP併用療法のランダム化第２相試験
  庄司広和, 伊澤直樹, 牧山明資, 他.

2021年度

2021.05 第43回日本癌局所療法研究会

• 切除不能胃癌に対してＳＰ療法後にcomversion surgery を施行し、長期生存が得られた1例
  高城伸平, 民上真也, 天野優希, 亀井奈津子, 嶋田仁, 榎本武治, 伊澤直樹, 津田亨志, 砂川優, 有泉泰, 大坪毅人.

2021.05 第62回日本神経学会学術大会

• 免疫チェックポイント阻害薬による中枢神経領域の免疫関連有害事象に関する検討.
  鏑木真弓, 水上平祐, 松本博文, 菱田吉明, 清水紗智, 緒方聖友, 韓蔚, 井澤直樹, 砂川優, 白石眞, 山野嘉久.

2021.05 第6回日本がんサポーティブケア学会学術集会

• The Implication of Neurofilament light chain and Galectin-3 in paclitaxel-induced peripheral neurotoxicity for patients with advanced gastric cancer.
  Hiroyuki Takeda, Shigenori Kadowaki, Takeshi Kajiwara, Keiko Minashi, Naoki Izawa, Kei Muro, Tomohiro Nishina, Shuichi Hironaka, Takeharu Yamanaka, Takako Eguchi Nakajima.
• 免疫チェックポイント阻害薬の免疫関連有害事象に対する治療前の抗体検査の意義.
  大貫理沙, 伊澤直樹, 濱地広毅, 塩川尚恵, 森川慶, 佐治久, 大橋洋之, 春日井滋, 早川望, 大原樹, 水上拓郎, 田中 恒明, 砂川優.

2021.06 第27回日本遺伝性腫瘍学会学術集会

• 当院におけるがん遺伝子パネル検査の二次的所見に関する検討.
  本吉愛, 右田王介, 小澤南, 高橋由妃, 杉下陽堂, 久我亜沙美, 大原樹, 古屋直樹, 小島康幸, 大橋洋之, 山本博幸, 井本清美, 砂川優, 山野嘉久, 津川浩一郎.

2021.09 第80回日本癌学会学術総会

• 胃癌における腸内細菌ゲノム情報と患者背景の関係：DELIVER 試験.
  砂川 優, 的場 亮, 佐藤 慶治, 川上 尚人, 室 圭, 中島 貴子, 市川 度.

2021.09 第52回日本膵臓学会大会

• 進行膵癌におけるリキッドバイオプシーと、KRAS野生型膵癌の治療開発に関する取り組み.
  梅本久美子、森実千種、中村能章、池田公史.
• Efficacy and safety of zenocutuzumab in advanced pancreatic cancer and other solid tumors harboring NRG1 fusions.
  Kumiko Umemoto, Ernesto Wasserman.

2021.10 第59回日本癌治療学会学術集会

• がん遺伝子パネル検査に基づいた治療提案と治療到達性.
  井本清美, 砂川 優, 武田弘幸, 大原 樹, 小島康幸, 古屋直樹, 大橋洋之, 山本博幸, 小池淳樹, 大川 千絵, 島田 直樹, 本吉 愛, 佐藤知雄, 谷嶋成樹, 山野嘉久.
• Genomic factors of gut microbiome associated with patient characteristics in gastric cancer: from the DELIVER trial (JACCRO GC-08).
  Yu Sunakawa, Ryo Matoba, Yoshiharu Sato, Toshizo Takayama, Takeharu Imai, Naotoshi Sugimoto, Kou Miura, Satoshi Yuki, Yoshiaki Shindo, Hisato Kawakami, Kei Muro, Takako Eguchi Nakajima, Wataru Ichikawa, and Masashi Fujii.

2021.11 第62回日本肺癌学会学術集会

• Efficacy and safety of zenocutuzumab in advanced pancreatic cancer and other solid tumors harboring NRG1 fusions.
  Alison M. Schram, Eileen Mary O’Reilly, Grainne M. O’Kane, Koichi Goto, Dong-Wan Kim, Cindy Neuzillet, Patricia Martin-Romano, Michaël Duruisseaux, Misako Nagasaka, Jordi Rodon, Benjamin Adam Weinberg, Kumiko Umemoto, Sai-Hong Ignatius Ou, Teresa Macarulla, Christelle De La Fouchardiere, Andrew K. Joe, Ernesto Wasserman, Viktoriya Stalbovskaya, Jim Ford, Alexander E. Drilon.

2021.11 厚生労働省「治療と仕事の両立支援」オンラインシンポジウム

• 聖マリアンナ医科大学病院における両立支援相談体制の構築と進捗. 厚生労働省「治療と仕事の両立支援」オンラインシンポジウム
  山野嘉久, 長谷川大輔, 萩原悠太, 山徳雅人, 桑島則夫, 杉浦貴子, 伊澤直樹, 梶ヶ谷和子, 高田礼子.

2022.02 第19回日本臨床腫瘍学会学術集会

• 遠隔医療を用いた治験プレスクリーニング検査の実装
  梅本久美子、砂川優、岩見さゆり、小林奈穂、松本生、斉藤修平、原聖吾.
• Evaluation of annotations for cancer gene panel testing using a genome-guided system.
  Yu Sunakawa, Peter Koch, Hiroyuki Yamamoto, Ai Motoyoshi, Kiyomi Imoto, Martin Maerz, and Yoshihisa Yamano.
• Symptom monitoring and its digitalization at daily cancer chemotherapy in Japan: a nation-wide multi-stakeholder survey.
  Horie Yoshiki, Miyaji Tempei, Kawaguchi Takashi, Kaneyasu Takako, Nagashima Fumio, Doi Ayako, Uneno Yu, Ogura Takashi, Yamaguchi Takuhiro, Nakajima Takako.
• FOLFOXIRI plus cetuximab versus bevacizumab in RAS wild-type mCRC: the subgroup-analysis of DEEPER trial (JACCRO CC-13).
  薮野 太一, 辻 晃仁, 徳永 卓哉, 結城 敏志, 工藤 敏啓, 間下 直樹, 安藤 幸滋, 竹内 信道, 柏田 知美, 片岡 政人, 東風 貢, 佐川 保, 小髙 雅人, 久保田 祐太郎, 砂川 優, 関川 高志, 中村 将人, 竹内 正弘, 市川 度, 藤井 雅志
• 抗EGFR抗体薬併用化学療法に不応/不耐となった進行再発大腸癌患者に対する2次治療：FOLFIRI/ラムシルマブ併用療法の第II相試験：JACCRO CC-16.
  佐川 保, 辻 晃仁, 佐竹 悠良, 中村 将人, 砂川 優, 是久 翔太郎, 松浦 正徒, 湯浅 康弘, 峯 孝志, 永野 浩昭, 重安 邦俊, 金城 達也, 小髙 雅人, 奥山 浩之, 久保田 祐太郎, 東風 貢, 舛石 俊樹, 竹内 正弘, 市川 度, 藤井 雅志
• Exploratory analysis of baseline tumor burden in the TRUSTY study: Phase 2/3 study of 2nd-line FTD/TPI + BEV for mCRC.
  中村 将人, 久保木 恭利, 寺澤 哲志, 舛石 俊樹, 渡邉 純, 尾嶋 仁, 牧山 明資, 小髙 雅人, 原 浩樹, 太田 高志, 沖 英次, 砂川 優, 石原 聡一郎, 谷口 浩也, 中島 貴子, 森田 智視, 白尾 國昭, 吉野 孝之
• Observational study to evaluate RAS status in ctDNA for mCRC patients with RAS mutant tumor: RASMEX study（JACCRO CC-17）.
  伊澤 直樹, 賀川 義規, 佐竹 悠良, 砂川 優, 竹内 正弘, 市川 度, 藤井 雅志
• Somatostatin receptor: a potential new therapeutic target for primary mucinous neoplasm of the appendix.
  水上 拓郎, 新井 裕之, 武田 弘幸, 土井 綾子, 堀江 良樹, 梅本 久美子, 伊澤 直樹, 砂川 優
• 切除不能進行結腸直腸癌における分子標的治療薬投与前後の血清VEGF-A, VEGF-D, PlGFの変動：GI-SCREEN CRC Ukit.
  結城 敏志, 砂川 優, 谷口 浩也, 坂東 英明, 山﨑 健太郎, 仁科 智裕, 太田 高志, 傳田 忠道, 江﨑 泰斗, 川上 尚人, 高島 淳生, 加藤 健志, 安藤 幸滋, 森脇 俊和, 佐藤 太郎, 奥川 喜永, 阿部 由紀子, 野村 尚吾, 淺野 千春, 吉野 孝之

2022.03 第94回日本胃癌学会総会

• A phase II, non-randomized, prospective trial of biweekly nab-paclitaxel in combination with ramucirumab for patients with previously treated advanced gastric or gastro-esophageal junction cancer: B-RAX trial (JACCRO GC-09)
  “Yoshio Nagahisa, Naoki Izawa, Takashi Mine, Masahiro Goto, Hitoshi Fujii, Yosuke Kito, Ryohei Kawabata, Masato Nakamura, Mizutomo Azuma, Akihito Tsuji, Mitsugu Kochi, Takao Takahashi, Shigenori Kadowaki, Hirofumi Michimae, Yu Sunakawa, Wataru Ichikawa, Masashi Fujii.

学会発表（国際学会）

2023年度

2023.06 ASCO

• Survival analysis by tumor response of nivolumab treatment in previously treated advanced gastric cancer from the DELIVER trial (JACCRO GC-08).
  Yu Sunakawa, Yasuhiro Sakamoto, Ryohei Kawabata, Atsushi Ishiguro, Yusuke Akamaru, Yosuke Kito, Masazumi Takahashi, Jin Matsuyama, Hiroshi Yabusaki, Akitaka Makiyama, Takahisa Suzuki, Masahiro Tsuda, Hisateru Yasui, Jun Hihara, Atsushi Takeno, Eisuke Inoue, Wataru Ichikawa, Masashi Fujii.
• Utility of multi-gene panel-based germline analysis following genomic profiling and cascade testing in advanced solid tumors: An initial report of the BRANCH study.
  Takeshi Kuwata, Yoshiaki Nakamura, Tomohiro Nishina, Naoki Takahashi, Hiroto Narimatsu, Hourin Cho, Chiaki Inagaki, Shigenori Kadowaki, Yoshinaga Okugawa, Sawako Matsuzaki, Naohiro Tomita, Hisateru Yasui, Yu Sunakawa, Manami Matsukawa, Kaori Kimura, Yumie Hiraoka, Makoto Hirata, Issei Imoto, Shinji Kosugi, Takayuki Yoshino.
• Tissue-agnostic efficacy of trastuzumab deruxtecan (T-DXd) in advanced solid tumors with HER2 amplification identified by plasma cell-free DNA (cfDNA) testing: Results from a phase 2 basket trial (HERALD/EPOC1806).
  Hiroya Taniguchi, Masataka Yagisawa, Taroh Satoh, Shigenori Kadowaki, Yu Sunakawa, Tomohiro Nishina, Yoshito Komatsu, Taito Esaki, Daisuke Sakai, Ayako Doi, Takeshi Kajiwara, Hiromi Ono, Masatoshi Asano, Nami Hirano, Justin Iver Odegaard, Satoshi Fujii, Shogo Nomura, Akihiro Sato, Takayuki Yoshino, Yoshiaki Nakamura.
• NeoRAS wild-type metastatic colorectal cancer in the SCRUM-Japan GOZILA study.
  Hiroki Osumi, Eiji Shinozaki, Yoshiaki Nakamura, Taito Esaki, Hisateru Yasui, Hiroya Taniguchi, Hironaga Satake, Yu Sunakawa, Yoshito Komatsu, Yoshinori Kagawa, Tadamichi Denda, Manabu Shiozawa, Taroh Satoh, Tomohiro Nishina, Masahiro Goto, Naoki Takahashi, Takeshi Kato, Hideaki Bando, Kensei Yamaguchi, Takayuki Yoshino.
• Tucatinib and trastuzumab for previously treated HER2-positive metastatic biliary tract cancer (SGNTUC-019): A phase 2 basket study.
  Yoshiaki Nakamura, Nobumasa Mizuno, Yu Sunakawa, Erika P. Hamilton, Hidetoshi Hayashi, Seung Tae Kim, Keun-Wook Lee, Bradley J. Monk, Danny Nguyen, Alicia Frances Clare Okines, David M. O’Malley, Paula R Pohlmann, Martin Reck, Evan Y. Yu, Roman Groisberg, Jorge Ramos, Qianwen Tan, Tom Stinchcombe, Tanios S. Bekaii-Saab.

2023.07 ESMO-GI

• RAS status in circulating-tumor DNA after chemotherapy in RAS mutant mCRC: the RASMEX study (JACCRO CC-17) .
  Shinichi Nishina, Naoki Izawa, Megumu Watabe, Toshihiko Matsumoto, Masato Kataoka, Akinori Sugaya, Tomomi Kashiwada, Eiji Oki, Akitaka Makiyama, Yoshihisa Yaguchi, Takashi Ohta, Tatsuya Toyokawa, Yasuyuki Miura, Kazuma Kobayashi, Yosuke Kito, Osamu Muto, Yoshinori Kagawa, Hironaga Satake, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii, Yu Sunakawa.

2022年度

2022.06 ASCO Annual Meeting

• Predictive value of CDC37 gene expression for targeted therapy in metastatic colorectal cancer (mCRC).
  Hiroyuki Arai, Yan Yang, Joshua Millstein, Tadamichi Denda, Fang-Shu Ou, Federico Innocenti, Hiroyuki Takeda, Ayako Doi, Yoshiki Horie, Kumiko Umemoto, Naoki Izawa, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Priya Jayachandran, Shivani Soni, Zhang Wu, Alan P. Venook, Yu Sunakawa, Heinz-Josef Lenz.
• Plasma RAS dynamics and anti-EGFR rechallenge efficacy in patients with RAS/BRAF wild-type metastatic colorectal cancer: REMARRY and PURSUIT trials.
  Yoshinori Kagawa, Daisuke Kotani, Hideaki Bando, Naoki Takahashi, Tetsuya Hamaguchi, Akiyoshi Kanazawa, Takeshi Kato, Koji Ando, Hironaga Satake, Eiji Shinozaki, Yu Sunakawa, Atsuo Takashima, Kentaro Yamazaki, Satoshi Yuki, Hiromichi Nakajima, Yoshiaki Nakamura, Masashi Wakabayashi, Hiroya Taniguchi, Takashi Ohta, Takayuki Yoshino.
• Analysis of plasma angiogenesis factors on the efficacy of first-line (1L) chemotherapy (chemo) combined with biologics in RAS wild-type metastatic colorectal cancer (mCRC): Results from GI-SCREEN CRC Ukit study.
  Satoshi Yuki, Yu Sunakawa, Kentaro Yamazaki, Hiromichi Shirasu, Hiroya Taniguchi, Toshiki Masuishi, Manabu Shiozawa, Hideaki Bando, Tomohiro Nishina, Hisateru Yasui, Takashi Ohta, Naoki Takahashi, Tadamichi Denda, Taito Esaki, Hisato Kawakami, Hironaga Satake, Atsuo Takashima, Yukiko Abe, Shogo Nomura, Takayuki Yoshino.
• Identification of an optimal circulating tumor DNA (ctDNA) shedding threshold to detect actionable driver mutations in colorectal and pancreatic adenocarcinoma.
  Bennett Adam Caughey, Kumiko Umemoto, Michelle Green, Masafumi Ikeda, Rachel D’Anna, Makoto Ueno, Donna Niedzwiecki, Hiroya Taniguchi, Daniel Walden, Yoshito Komatsu, Katherine I. Zhou, Taito Esaki, Ryne Ramaker, Tadamichi Denda, Michael Datto, Hideaki Bando, Tanios S. Bekaii-Saab, Takayuki Yoshino, John H Strickler, Yoshiaki Nakamura.
• Efficacy and safety of zenocutuzumab, a HER2 x HER3 bispecific antibody, in advanced NRG1 fusion-positive (NRG1+) cancer.
  Alison M Schram, Koichi Goto, Dong-Wan Kim, Patricia Martin-Romano, Sai-Hong I Ou, Grainne M O’Kane, Eileen M O’Reilly, Kumiko Umemoto, Michaël Duruisseaux, Cindy Neuzillet, Frans Opdam, Jordi Rodon Ahnert, Misako Nagasaka, Benjamin A Weinberg, Teresa Macarulla, Andrew K Joe, Jim Ford, Viktoriya Stalbovskaya, Ernesto Wasserman, Alexander E Drilon.

2022.06 ASCO Plenary Series

• First data for sotorasib in patients with pancreatic cancer with KRAS p.G12C mutation: A phase I/II study evaluating efficacy and safety.
  John H Strickler, Hironaga Satake, Antoine Hollebecque, Yu Sunakawa, Pascale Tomasini, David Lawrence Bajor, Martin H. Schuler, Rona Yaeger, Thomas J. George, Ignacio Garrido-Laguna, Andrew L. Coveler, Mark David Vincent, Gerald Steven Falchook, Timothy F. Burns, Sun Young Rha, Charlotte Rose Lemech, Dejan Juric, Pegah Jafarinasabian, Qui Tran, David Hong.

2022.06 ESMO-GI

• An observational/translational study of BRAF inhibitor combination therapy for BRAF-mutant metastatic colorectal cancer including biomarker research: BEETS trial (JACCRO CC-18).
  Y. Sunakawa, C. Inagaki, S. Yuki, M. Shiozawa, A. Tsuji, R. Matoba, E. Inoue, K. Muro, W. Ichikawa.
• Plasma RAS dynamics and efficacy of anti-EGFR rechallenge in patients with RAS/BRAF wild-type metastatic colorectal cancer: REMARRY and PURSUIT trials.
  Y. Kagawa, D. Kotani, H. Bando, N. Takahashi, Y. Horita, A. Kanazawa, T. Kato, K. Ando, H. Satake, E. Shinozaki, Y. Sunakawa, A. Takashima, K. Yamazaki, S. Yuki, H. Nakajima, Y. Nakamura, M.Wakabayashi, H. Taniguchi, T. Ohta, T. Yoshino.
• Efficacy of 2nd-line ramucirumab (RAM) plus FOLFIRI for RAS wild-type metastatic colorectal cancer (mCRC) by prior regimen: Subgroup analysis of the JACCRO CC-16.
  Y. Okita, A. Tsuji, T. Watanabe, H. Satake, M. Goto, H. Yasui, M. Nakamura, T. Sagawa, K. Kataoka, M. Shiozawa, Y. Sunakawa, H. Ota, M. Kotaka, K. Miwa, Y. Kobayashi, H. Okuyama, M. Kochi, T. Masuishi, M. Takeuchi, W. Ichikawa, M. Fujii.
• An observational study of health-related quality of life (HRQoL) with electronic patient-reported outcome (ePRO) monitoring during nivolumab therapy for advanced gastric cancer as the 3rd or later line treatment: NIVO-G QoL study.
  H. Kawakami, S. Oyamada, Y. Horie, S. Fumita, N. Izawa, T. Miyaji, T. Kawaguchi, T. Yamaguchi, T. Nakajima.

2022.09 ESMO

• Final analysis of clinical outcomes in the DELIVER trial: Observational study of nivolumab treatment in advanced gastric cancer (JACCRO GC-08).
  Y Sunakawa, E Inoue, Y Sakamoto, R Kawabata, A Ishiguro, Y Akamaru, Y Kito, M Takahashi, J Matsuyama, H Yabusaki, A Makiyama, T Suzuki, M Tsuda, H Yasui, H Kawakami, TE Nakajima, K Muro, R Matoba, W Ichikawa, M Fujii.

2023.01 ASCO-GI

• Outcomes of FOLFIRINOX and gemcitabine plus nab-paclitaxel in patients with early recurrent pancreatic cancer after adjuvant S-1: A propensity score–matching analysis.
  Naohiro Okano, Kentaro Sakamaki, Takafumi Mie, Kazuo Watanabe, Satoshi Kobayashi, Akiko Todaka, Yuko Suzuki, Hidetoshi Kitamura, Kazunari Tanaka, Kei Nakagawa, Keiko Kamei, Kumiko Umemoto, Nobuaki Azemoto, Yasuyuki Kawamoto, Hiroaki Yanagimoto, Kunihiro Tsuji, Hiroshi Imaoka, Takeshi Terashima, Makoto Ueno, Junji Furuse.
• Interim analysis results of gut microbiota in patients with unresectable cholangiopancreatic cancer: SCRUM-Japan MONSTAR-SCREEN.
  Shun Tezuka, Shunsuke Sakai, Riu Yamashita, Satoshi Horasawa, Takao Fujisawa, Kentaro Sawada, Ayumu Yoshikawa, Yoshiaki Nakamura, Kumiko Umemoto, Nobuhiro Shibata, Koushiro Ohtsubo, Shinji Itoh, Akiko Todaka, Kentaro Sudo, Masayuki Furukawa, Masafumi Ikeda, Chigusa Morizane, Makoto Ueno, Takayuki Yoshino.
• Plasma biomarkers to predict clinical outcomes of FOLFIRI plus ramucirumab (RAM) as second-line treatment for RAS wild-type metastatic colorectal cancer: JACCRO CC-16AR.
  Yu Sunakawa, Hisateru Yasui, Manabu Shiozawa, Hiroyuki Takeda, Naoya Akazawa, Tamotsu Sagawa, Kazuhiro Shiraishi, Yoshihiro Okita, Hiroyuki Okuyama, Satoshi Yuki, Shoko Yanaka, Koutatsu Matsushima, Koki Miyakawa, Ayana Kobara, Wataru Ichikawa, Masashi Fujii, Akihito Tsuji.
• Modified (m)-FOLFOXIRI plus cetuximab versus m-FOLFOXIRI plus bevacizumab as initial treatment of patients with unresectable RAS and BRAF wild-type metastatic colorectal cancer: Survival analysis of the phase II randomized DEEPER trial by JACCRO.
  Yu Sunakawa, Manabu Shiozawa, Takanori Watanabe, Hirofumi Ota, Hisateru Yasui, Taichi Yabuno, Mitsuyoshi Tei, Mitsugu Kochi, Dai Manaka, Hisatsugu Ohori, Tatsuro Yamaguchi, Tamotsu Sagawa, Masahito Kotaka, Yutaro Kubota, Takashi Sekikawa, Masato Nakamura, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii, Akihito Tsuji.
• Post-recurrent survival of a phase III trial comparing adjuvant chemotherapy with docetaxel plus S-1 versus S-1 alone in stage III gastric cancer: A post-hoc analysis of the START-2 trial (JACCRO GC-07).
  Hiroo Ishida, Yu Sunakawa, Yasuhiro Kodera, Kazuhiro Yoshida, Mitsugu Kochi, Yoshihiro Kakeji, Takeshi Sano, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii.

2021年度

2021.06 ASCO Annual Meeting

• Efficacy and safety of zenocutuzumab in advanced pancreatic cancer and other solid tumors harboring NRG1 fusions.
  Alison M. Schram, Eileen Mary O’Reilly, Grainne M. O’Kane, Koichi Goto, Dong-Wan Kim, Cindy Neuzillet, Patricia Martin-Romano, Michaël Duruisseaux, Misako Nagasaka, Jordi Rodon, Benjamin Adam Weinberg, Kumiko Umemoto, Sai-Hong Ignatius Ou, Teresa Macarulla, Christelle De La Fouchardiere, Andrew K. Joe, Ernesto Wasserman, Viktoriya Stalbovskaya, Jim Ford, Alexander E. Drilon.
• Profiling plasma angiogenesis factors after use of biologics in metastatic colorectal cancer (mCRC); Update results from GI-SCREEN CRC Ukit study.
  Yu Sunakawa, Satoshi Yuki, Manabu Shiozawa, Toshiki Masuishi, Tomohiro Nishina, Hisateru Yasui, Takashi Ohta, Naoki Takahashi, Hironaga Satake, Akiyoshi Kanazawa, Masahiro Goto, Hideaki Bando, Hiroya Taniguchi, Yoshinaga Okugawa, Kentaro Yamazaki, Hiromichi Ebi, Yukiko Abe, Shogo Nomura, Chiharu Asano, Takayuki Yoshino.
• The randomized phase II study of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab as the first-line treatment in metastatic colorectal cancer with RAS wild-type tumors: The DEEPER trial (JACCRO CC-13).
  HisatsuguOhori, TatsuroYamaguchi, Masato Matsuura, AtsujiroNishioka, AkitakaMakiyama, Shingo Noura, MitsuguKochi, Tamotsu Sagawa, Masahito Kotaka, YutaroKubota, Yu Sunakawa, Takashi Sekikawa, Masato Nakamura, Masahito Takeuchi, WataruIchikawa and Masashi Fujii.
• Genomic alterations for novel targeted therapies in pancreatobiliary cancers from real-world data.
  Kumiko Umemoto, Hiroyuki Yamamoto, Ritsuko Oikawa, Hiroyuki Takeda, Ayako Doi, Yoshiki Horie, Takashi Ogura, Takuro Mizukami, Naoki Izawa, Jay A. Moore, Ethan S. Sokol, Yu Sunakawa

2021.06 MASCC

• The Implication of Neurofilament light chain and Galectin-3 in paclitaxel-induced peripheral neurotoxicity for patients with advanced gastric cancer.
  Hiroyuki Takeda, Shigenori Kadowaki, Takeshi Kajiwara, Keiko Minashi, Naoki Izawa, Kei Muro, Tomohiro Nishina, Shuichi Hironaka, Takeharu Yamanaka, Takako Eguchi Nakajima.

2021.07 ESMO-GI

• Gut microbiome to predict survival time in advanced gastric cancer treated with nivolumab: the DELIVER trial (JACCRO GC-08).
  Yu Sunakawa, Ryo Matoba, Eisuke Inoue, Yasuhiro Sakamoto, Ryohei Kawabata, Atsushi Ishiguro, Yusuke Akamaru, Yosuke Kito, Masazumi Takahashi, Jin Matsuyama, Hiroshi Yabusaki, Akitaka Makiyama, Takahisa Suzuki, Masahiro Tsuda, Hisateru Yasui, Jun Hihara, Atsushi Takeno, Hisato Kawakami, Kei Muro, Takako Eguchi Nakajima, Wataru Ichikawa, and Masashi Fujii.
• A multicenter phase Ⅱ trial of trifluridine/thipiracil in combination with cetuximab in RAS wild-type metastatic colorectal cancer patients refractory to prior anti-EGFR antibody：the WJOG8916G trial.
  T. Masuishi, N. Izawa, N. Takahashi, H. Shoji, Y. Yamamoto, T. Matsumoto, K. Sugiyama, T. Kajiwara, K. Kawakami, N. Aomatsu, C. Kondoh, H. Kawakami, N. Takegawa, T. Esaki, Y. Narita, H. Hara, Y. Sunakawa, N. Boku, T. Moriwaki, M. Shimokawa, TE. Nakajima, K. Muro.
• Gene alterations in ctDNA related to the resistance mechanism of anti-EGFR antibodies and clinical efficacy outcomes of anti-EGFR antibody rechallenge plus trifluridine/tipiracil in metastatic colorectal cancer patients in WJOG8916G trial.
  N. Takahashi, N. Izawa, K. Nishio, T. Masuishi, H. Shoji, Y. Yamamoto, T. Matsumoto, K. Sugiyama, T. Kajiwara, K. Kawakami, N. Aomatsu, H. Kawakami, T. Esaki, Y. Narita, H. Hara, Y. Horie, N. Boku, T. Moriwaki, K. Miura, M. Shimokawa, TE. Nakajima, K. Muro.

2021.09 ESMO

• Impact of plasma angiogenesis factors on the efficacy of 2nd-line chemotherapy combined with biologics in metastatic colorectal cancer (mCRC); Early efficacy results from GI-SCREEN CRC Ukit study.
  Satoshi Yuki, Hiroya Taniguchi, Toshiki Masuishi, Manabu Shiozawa, Hideaki Bando, Kentaro Yamazaki, Tomohiro Nishina, Hisateru Yasui, Tadamichi Denda, Yu Sunakawa, Hironaga Satake, Kazuhiro Yoshida, Akiyoshi Kanazawa,Eiji Oki, Yoshinaga Okugawa, Hiromichi Ebi, Yukiko Abe, Shogo Nomura, Chiharu Asano, Takayuki Yoshino.
• Genomic landscape in advanced gastric cancer from real-world data (RWD) of clinical genomic testing.
  H. Yamamoto, R. Oikawa, H. Takeda, K. Umemoto, A. Doi, Y. Horie, T. Ogura, T. Mizukami, N. Izawa, J.A. Moore, E. Sokol, Y. Sunakawa.
• Placebo-controlled, double-blinded phase Ⅲ study comparing dexamethasone on day 1 with dexamethasone on days 1 to 4, with combined neurokinin-1 receptor antagonist, palonosetron, and olanzapine in patients receiving cisplatin-containing highly emetogenic chemotherapy: SPARED Trial.
  K. Shimomur, H. Minatogawa, T. Mashiko, H. Arioka, H. Iihara, M. Sugawara, N.Hida, K. Akiyama, S. Nawata, A. Tsuboya, K. Mishima, N. Izawa, T. Miyaji, K.Honda, Y. Inada, Y. Ohno, C. Katada, H. Morita, T. Yamaguchi, TE. Nakajima.

2022.01 ASCO-GI

• A phase II, non-randomized, prospective trial of biweekly nab-paclitaxel in combination with ramucirumab for patients with previously treated advanced gastric or gastro-esophageal junction cancer: B-RAX trial (JACCRO GC-09).
  Takahisa Suzuki, Naoki Izawa, Ryohei Kawabata, Kazuhiro Nishikawa, Masazumi Takahashi, Masato Nakamura, Atsushi Ishiguro, Hiroo Katsuya, Jun Hihara, Dai Manaka, Yuji Negoro, Mizutomo Azuma, Akihito Tsuji, Mitsugu Kochi, Takao Takahashi, Shigenori Kadowaki, Hirofumi Michimae, Yu Sunakawa, Wataru Ichikawa, Masashi Fujii.
• An observational study to evaluate RAS mutations in circulating tumor DNA after standard chemotherapies for metastatic colorectal cancer patients with tumors harboring RAS mutation: RASMEX study (JACCRO CC-17).
  Naoki Izawa, Yoshinori Kagawa, Hironaga Satake, Yu Sunakawa, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii.
• A multicenter phase 2 trial of ramucirumab plus FOLFIRI as second-line treatment for patients with RAS wild-type metastatic colorectal cancer previously treated with combination chemotherapy with anti-EGFR antibody: JACCRO CC-16.
  Masato Nakamura, Akihito Tsuji, Yoshihiro Okita, Toshihiko Matsumoto, Tamotsu Sagawa, Takanori Watanabe, Kozo Kataoka, Dai Manaka, Kazuhiro Shiraishi, Naoya Akazawa, Tatsuya Okuno, Takaya Shimura, Manabu Shiozawa, Shingo Noura, Yu Sunakawa, Yasuki Akiyama, Hirofumi Ota, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii.
• Exploratory analysis of baseline tumor burden in the TRUSTY study: A randomized phase 2/3 study of trifluridine/tipiracil plus bevacizumab versus irinotecan and fluoropyrimidine plus bevacizumab as second-line treatment in patients with metastatic colorectal cancer.
  Toshiki Masuishi, Yasutoshi Kuboki, Tetsuji Terazawa, Masato Nakamura, Jun Watanabe, Hitoshi Ojima, Akitaka Makiyama, Masahito Kotaka, Hiroki Hara, Takashi Ohta, Eiji Oki, Yu Sunakawa, Soichiro Ishihara, Hiroya Taniguchi, Takako Eguchi Nakajima, Satoshi Morita, Kuniaki Shirao, Takayuki Yoshino.
• Host-related biomarkers including gut microbiome to predict toxicities of nivolumab in advanced gastric cancer: DELIVER trial (JACCRO GC-08).
  Yu Sunakawa, Ryo Matoba, Toshizo Takayama, Naoki Okumura, Naotoshi Sugimoto, Kou Miura, Satoshi Yuki, Yoshiaki Shindo, Hidekazu Kuramochi, Sho Sato, Takashi Ogura, Shinichi Kinami, Narutoshi Nagao, Shugo Ueda, Eisuke Inoue, Hisato Kawakami, Kei Muro, Takako Eguchi Nakajima, Wataru Ichikawa, Masashi Fujii.
• Tumor response of FOLFOXIRI plus cetuximab versus bevacizumab in RAS wild-type metastatic colorectal cancer: The subgroup-analysis of DEEPER trial (JACCRO CC-13).
  Hironaga Satake, Akihito Tsuji, Chihiro Tanaka, Takao Takahashi, Kunihiko Wakamura, Taichi Yoshida, Kohei Murata, Yoshiaki Shindo, Yasuhide Ishikawa, Ken Konishi, Mitsugu Kochi, Tamotsu Sagawa, Masahito Kotaka, Yutaro Kubota, Yu Sunakawa, Takashi Sekikawa, Masato Nakamura, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii.
• Genomic landscape in small intestine cancer from real-world data (RWD) of clinical genomic testing.
  Hiroyuki Takeda, Hiroyuki Yamamoto, Ritsuko Oikawa, Kumiko Umemoto, Ayako Doi, Yoshiki Horie, Takuro Mizukami, Takashi Ogura, Naoki Izawa, Jay A. Moore, Ethan Sokol, Yu Sunakawa.

論文業績（和文）

2023年度

《原著・総説・解説》

1. 若年膵癌とKRAS変異

• 胆と膵, 44(7)：661-663.
• 梅本久美子

2021年度

《原著・総説・解説》

1. 消化器癌；診断・治療のすべて

• 化学療法, 44(6)：608-614.
• 伊澤直樹、砂川優

論文業績（英文）

《2023年度》

《原著・総説・解説》

1. A Multicenter, Phase II Trial of Schedule Modification for Nab-Paclitaxel in Combination with Ramucirumab for Patients with Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer: The B-RAX Trial (JACCRO GC-09).

• Target Oncol. 18(3):359-368, 2023.
• Ryohei Kawabata, Naoki Izawa, Takahisa Suzuki, Yoshio Nagahisa, Kazuhiro Nishikawa, Masazumi Takahashi, Masato Nakamura, Atsushi Ishiguro, Hiroo Katsuya, Jun Hihara, Dai Manaka, Yuji Negoro, Akihito Tsuji, Takao Takahashi, Mitsugu Kochi, Mizutomo Azuma, Shigenori Kadowaki, Hirofumi Michimae, Yu Sunakawa, Wataru Ichikawa, Masashi Fujii.

2. A Phase II Trial of Trifluridine/Tipiracil in Combination with Cetuximab Rechallenge in Patients with RAS Wild-Type mCRC Refractory to Prior Anti-EGFR Antibodies: WJOG8916G Trial.

• Target Oncol. 18(3):369-381, 2023.
• Naoki Izawa, Toshiki Masuishi, Naoki Takahashi, Hirokazu Shoji, Yoshiyuki Yamamoto, Toshihiko Matsumoto, Keiji Sugiyama, Takeshi Kajiwara, Kentaro Kawakami, Naoki Aomatsu, Chihiro Kondoh, Hisato Kawakami, Naoki Takegawa, Taito Esaki, Mototsugu Shimokawa, Kazuto Nishio, Yukiya Narita, Hiroki Hara, Yu Sunakawa, Narikazu Boku, Toshikazu Moriwaki, Takako Eguchi Nakajima, Kei Muro.

3. Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11).

• ESMO Open. 7(3):100512.
• Sunakawa Y, Satake H, Usher J, Jaimes Y, Miyamoto Y, Nakamura M, Kataoka M, Shiozawa M, Takagane A, Terazawa T, Watanabe T, Ishiguro K, Tanaka C, Takeuchi M, Fujii M, Danenberg K, Danenberg PV, Lenz HJ, Sekikawa T, Ichikawa W.

4. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer.

• ESMO Open. 8(3):101558.
• Yoshino T, Cervantes A, Bando H, Martinelli E, Oki E, Xu RH, Mulansari NA, Govind Babu K, Lee MA, Tan CK, Cornelio G, Chong DQ, Chen LT, Tanasanvimon S, Prasongsook N, Yeh KH, Chua C, Sacdalan MD, Sow Jenson WJ, Kim ST, Chacko RT, Syaiful RA, Zhang SZ, Curigliano G, Mishima S, Nakamura Y, Ebi H, Sunakawa Y, Takahashi M, Baba E, Peters S, Ishioka C, Pentheroudakis G.

5. A Phase II Trial of Trifluridine/Tipiracil in Combination with Cetuximab Rechallenge in Patients with RAS Wild-Type mCRC Refractory to Prior Anti-EGFR Antibodies: WJOG8916G Trial.

• Target Oncol. 18(3):369-381.
• Izawa N, Masuishi T, Takahashi N, Shoji H, Yamamoto Y, Matsumoto T, Sugiyama K, Kajiwara T, Kawakami K, Aomatsu N, Kondoh C, Kawakami H, Takegawa N, Esaki T, Shimokawa M, Nishio K, Narita Y, Hara H, Sunakawa Y, Boku N, Moriwaki T, Eguchi Nakajima T, Muro K.

6. A Multicenter, Phase II Trial of Schedule Modification for Nab-Paclitaxel in Combination with Ramucirumab for Patients with Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer: The B-RAX Trial (JACCRO GC-09).

• Target Oncol. 18(3):359-368.
• Kawabata R, Izawa N, Suzuki T, Nagahisa Y, Nishikawa K, Takahashi M, Nakamura M, Ishiguro A, Katsuya H, Hihara J, Manaka D, Negoro Y, Tsuji A, Takahashi T, Kochi M, Azuma M, Kadowaki S, Michimae H, Sunakawa Y, Ichikawa W, Fujii M.

7. Efficacy of Targeted Trials and Signaling Pathway Landscape in Advanced Gastrointestinal Cancers From SCRUM-Japan GI-SCREEN: A Nationwide Genomic Profiling Program.

• JCO Precis Oncol. 7:e2200653.
• Nakamura Y, Yamashita R, Okamoto W, Komatsu Y, Yuki S, Ueno M, Kato K, Taniguchi H, Kagawa Y, Denda T, Hara H, Esaki T, Moriwaki T, Sunakawa Y, Oki E, Nagashima F, Nishina T, Satoh T, Kawakami H, Yamaguchi K, Ohtsubo K, Kato T, Horita Y, Tsuji A, Yasui H, Goto M, Hamamoto Y, Wakabayashi M, Ikeno T, Shitara K, Bando H, Tsuchihara K, Miki I, Ichiki H, Ohtsu A, Yoshino T.

8. Soluble programmed cell death ligand 1 predicts prognosis for gastric cancer patients treated with nivolumab: Blood-based biomarker analysis for the DELIVER trial.

• Eur J Cancer. 184:10-20.
• Kawakami H, Sunakawa Y, Inoue E, Matoba R, Noda K, Sato T, Suminaka C, Yamaki M, Sakamoto Y, Kawabata R, Ishiguro A, Akamaru Y, Kito Y, Yabusaki H, Matsuyama J, Takahashi M, Makiyama A, Hayashi H, Chamoto K, Honjo T, Nakagawa K, Ichikawa W, Fujii M.

9. Trifluridine/tipiracil+bevacizumab (BEV) vs. fluoropyrimidine-irinotecan+BEV as second-line therapy for metastatic colorectal cancer: a randomised noninferiority trial.

• Br J Cancer. 128(10):1897-1905.
• Kuboki Y, Terazawa T, Masuishi T, Nakamura M, Watanabe J, Ojima H, Makiyama A, Kotaka M, Hara H, Kagawa Y, Sugimoto N, Kawakami H, Takashima A, Kajiwara T, Oki E, Sunakawa Y, Ishihara S, Taniguchi H, Nakajima TE, Morita S, Shirao K, Takenaka N, Ozawa D, Yoshino T.

10. Clinial utility of geriatric assessment tools in older patients with gastrointestinal cancer.

• Frontiers in oncology. eCollection 2023.
• Ayako Doi, Takuro Mizukami, Hiroyuki Takeda, Kumiko Umemoto, Hiroyuki Arai, Yoshiki Horie, Naoki Izawa, Takashi Ogura, Yu Sunakawa.

11. Phase II clinical trial to study the safety and efficacy of combined S-1 + oxaliplatin therapy as neoadjuvant chemotherapy for locally advanced gastric cancer in older patients.

• International journal of clinical oncology. Online ahead of print.
• Mitsuhiko Ota, Hiroshi Saeki, Hideo Uehara, Yoshiko Matsuda, Satoshi Tsutsumi, Tetsuya Kusumoto, Hisateru Yasui, Yasunari Ubukata, Shohei Yamaguchi, Hiroyuki Orita, Naoki Izawa, Saburo Kakizoe, Mototsugu Shimokawa, Tomoharu Yoshizumi, Yoshihiro Kakeji, Masaki Mori, Eiji Oki.

12. Clinical Validation of Plasma-Based Genotyping for RAS and BRAF V600E Mutation in Metastatic Colorectal Cancer: SCRUM-Japan GOZILA Substudy.

• JCO Precision Oncology. 7:e2200688.
• Yu Aoki, Yoshiaki Nakamura, Tadamichi Denda, Takashi Ohta, Taito Esaki, Manabu Shiozawa, Kensei Yamaguchi, Kentaro Yamazaki, Yu Sunakawa, Takeshi Kato, Naohiro Okano, Hiroya Taniguchi, Taro Sato, Eiji Oki, Tomohiro Nishina, Yoshito Komatsu Nobuhisa Matsuhashi, Masahiro Goto, Hisateru Yasui, Koushiro Ohtsubo, Toshikazu Moriwaki, Naoki Takahashi, Yosuke Horita, Shogen Boku, Masashi Wakabayashi, Takashi Ikeno, Ryuta Mitani, Mihoko Yuasa, Takayuki Yoshino.

13. Comprehensive review of undifferentiated carcinoma of the pancreas: from epidemiology to treatment.

• Japanese journal of clinical oncology. 15;hyad062.
• Hiroshi Imaoka, Masafumi Ikeda, Kumiko Umemoto, Yu Sunakawa, Makoto Ueno, Hideki Ueno, Masato Ozaka, Takamichi Kuwahara, Naohiro Okano, Masashi Kanai, Terumasa Hisano, Yuko Suzuki, Akinori Asagi, Kazuhiko Shioji, Akiko Todaka, Kunihiro Tsuji, Kenji Ikezawa, Ikuya Miki, Yoshito Komatsu, Noriyuki Akutsu, Tatsuya Yamashita, Hiroyuki Okuyama, Junji Furuse, Hiroaki Nagano.

14. Mutational spectrum of TP53 gene correlates with nivolumab treatment efficacy in advanced gastric cancer (TP53MUT study)

• British Journal of Cancer, Oct;129(6):1032-1039.
• Eiji Oki, Koji Ando, Yoshiaki Nakamura, Hiroyuki Kitao, Mototsugu Shimokawa, Daisuke Kotani, Hideaki Bando, Tomohiro Nishina, Takanobu Yamada, Satoshi Yuki, Yukiya Narita, Hiroki Hara, Takashi Ohta, Taito Esaki, Yasuo Hamamoto, Ken Kato, Yoshiyuki Yamamoto, Keiko Minashi, Koushiro Ohtsubo, Naoki Izawa, Hisato Kawakami, Takeshi Kato, Taroh Satoh, Naohiro Okano, Akihito Tsuji, Kentaro Yamazaki, Takayuki Yoshino, and Yoshihiko Maehara.

15. Real-World Treatment Sequencing in Vulnerable Patients with Metastatic Colorectal Cancer: A Multicenter Retrospective Study

• Target Oncol., Sep;18(5):707-715.
• Seiichiro Mitani, Yosuke Kito, Kaori Hino, Kentaro Kawakami, Naoki Izawa, Fumiyasu Hanamura, Yoshiyuki Yamamoto, Hirokazu Shoji, Azusa Komori, Shogen Boku, Kenji Tsuchihashi, Kyoko Kato, Yoshikane Nonagase, Toshihiko Matsumoto, Mitsuhiro Furuta, Hisato Kawakami.

《2022年度》

《原著・総説・解説》

1. Impact of Body Weight Loss on Survival in Patients with Advanced Gastric Cancer Receiving Second-Line Treatment.

• Nutr Cancer, 74(2):539-545, 2022.
• Mizukami T, Hamaji K, Onuki R, Yokomizo A, Nagashima Y, Takeda H, Umemoto K, Doi A, Arai H, Hirakawa M, Horie Y, Izawa N, Ogura T, Tsuda T, Sunakawa Y, Shibata M, Tanaka T, Mikami S, Nakajima TE.

2. The clinical utility of comprehensive measurement of autoimmune disease-related antibodies in patients with advanced solid tumors receiving immune checkpoint inhibitors: a retrospective study.

• ESMO Open, 7(2):100415, 2022.
• Izawa N, Shiokawa H, Onuki R, Hamaji K, Morikawa K, Saji H, Ohashi H, Kasugai S, Hayakawa N, Ohara T, Sunakawa Y

3. Effects of Metastatic Sites on Circulating Tumor DNA in Patients With Metastatic Colorectal Cancer.

• JCO Precis Oncol, Apr;6:e2100535., 2022.
• Bando H, Nakamura Y, Taniguchi H, Shiozawa M, Yasui H, Esaki T, Kagawa Y, Denda T, Satoh T, Yamazaki K, Sunakawa Y, Kato T, Goto M, Yuki S, Nishina T, Oki E, Shinozaki E, Matsuhashi N, Takahashi N, Tsuji A, Ohtsubo K, Wakabayashi M, Ikeno T, Hata M, Odegaard JI, Yoshino T.

4. Phase II Study of S-1 and Irinotecan Plus Bevacizumab as Second-line Treatment for Patients With Metastatic Colorectal Cancer Resistant to the Fluoropyrimidine-oxaliplatin-cetuximab Regimen.

• Anticancer Res, 42(5)：2675-2681, 2022.
• Tanioka H, Shimada K, Tsuji A, Kochi M, Kim HM, Takahashi T, Denda T, Takagane A, Watanabe T, Kotaka M, Nakamura M, Sunakawa Y, Takeuchi M, Ichikawa W, Fujii M.

5. Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial.

• Clin Colorectal Cancer, 21(3)：259-266, 2022.
• Hiroyuki Arai, Joshua Millstein, Yan Yang, Sebastian Stintzing, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Priya Jayachandran, Shivani Soni, Wu Zhang, V3olker Heinemann, Heinz-Josef Lenz.

6. NOTCH gene alterations in metastatic colorectal cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN).

• J Cancer Res Clin Oncol, 148(10):2841-2854, 2022.
• Kajiwara T, Nishina T, Nakasya A, Yamashita N, Yamashita R, Nakamura Y, Shiozawa M, Yuki S, Taniguchi H, Hara H, Ohta T, Esaki T, Shinozaki E, Takashima A, Moriwaki T, Denda T, Ohtsubo K, Sunakawa Y, Horita Y, Kawakami H, Kato T, Satoh T, Ando K, Mizutani T, Yasui H, Goto M, Okuyama H, Yamazaki K, Yoshino T, Hyodo I.

7. The molecular landscape of pancreatobiliary cancers for novel targeted therapies from real-world genomic profiling.

• J Natl Cancer Inst, 114(9):1279-1286, 2022.
• Umemoto K, Yamamoto H, Oikawa R, Takeda H, Doi A, Horie Y, Arai H, Ogura T, Mizukami T, Izawa N, Moore JA, Sokol ES, Sunakawa Y.

8. Genomic Landscape of Primary Tumor Site and Clinical Outcome for Patients with Metastatic Colorectal Cancer Receiving Standard-of-Care Chemotherapy.

• Targeted Oncology, 17(3):343-353, 2022.
• Mizukami T, Takahashi M, Sunakawa Y, Yuki S, Kagawa Y, Takashima A, Kato K, Hara H, Denda T, Yamamoto Y, Shiozawa M, Oki E, Okamoto W, Yoshino T, Eguchi Nakajima T.

9. fdrci: FDR confidence interval selection and adjustment for large-scale hypothesis testing.

• Bioinform Adv, 13;2(1):vbac047, 2022.
• Joshua Millstein, Francesca Battaglin, Hiroyuki Arai, Wu Zhang, Priya Jayachandran, Shivani Soni, Aparna R Parikh, Christoph Mancao, Heinz-Josef Lenz.

10. Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials.

• Eur J Cancer, 21;172:22-30, 2022.
• Jingyuan Wang, Yi Xiao, Fotios Loupakis, Sebastian Stintzing, Yan Yang, Hiroyuki Arai, Francesca Battaglin, Natsuko Kawanishi, Priya Jayachandran, Shivani Soni, Wu Zhang, Christoph Mancao, Chiara Cremolini, Tianshu Liu, Volker Heinemann, Alfredo Falcone, Lin Shen, Joshua Millstein, Heinz-Josef Lenz.

11. Rationale and design of a multicenter, double-blinded, randomized, placebo-controlled trial to investigate the effects of naldemedine on opioid-induced constipation for patients with cancer pain: A study protocol.

• Contemporary Clinical Trials Communications, 29:doi-10.1016/j.conctc.2022.100967, 2022.
• Higashibata Takahiro, Hamano Jun, Kessoku Takaomi, Kajiura Shinya, Hirakawa Mami, Horie Yoshiki, Shimizu Masaki, Oyamada Shunsuke, Ariyoshi Keisuke, Kihara Kota, Yamanaka Yohei, Konishi Kumi, Doki Kosuke, Takashima Yasuyuki, Horiuchi Manabu, Homma Masato, Yamada Takeshi, Yamamoto Yoshiyuki, Moriwaki Toshikazu, Morita Tatsuya, Nakajima Atsushi, Nagaoka Hiroka

12. A phase II study to explore biomarkers for the use of mFOLFOX6/XELOX plus bevacizumab as a first-line chemotherapy in patients with metastatic colorectal cancer (WJOG7612GTR)

• ESMO Open, 2022 Dec;7(6):100592, 2022.
• Okamoto W, Sakai K, Makiyama A, Yamamoto Y, Shitara K, Denda T, Izawa N, Nakano Y, Nishina T, Esaki T, Hara H, MiuraY, Boku N, Yamazaki K, Hironaka S, Misumi T, Hyodo I, Muro K, Nishio K.

13. Role of Nivolumab in the Management of First-Line Unresectable Advanced or Recurrent Gastric Cancer in Combination with Chemotherapy: Lessons from the Japanese Experience

• Cancer Management and Research, (14):3083-3094, 2022.
• Yohei Kubota, Yu Aoki, Akihito Kawazoe, Kohei Shitara.

14. Phase I study of envafolimab (KN035), a novel subcutaneous single-domain anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors

• Invest New Drugs, 40(5):1021-1031, 2022.
• Shimizu T, Nakajima TE, Yamamoto N, Yonemori K, Koyama T, Kondo S, Sunakawa Y, Izawa N, Horie Y, Xiang S, Xu S, Qin L, Gong J, Liu D.

15. Comparing the Efficacy and Safety of Gemcitabine plus Nab-Paclitaxel versus Gemcitabine Alone in Older Adults with Unresectable Pancreatic Cancer

• The Oncologist,27(10):e774-e782, 2022.
• Kobayashi, S.Suzuki, M.Ueno, M.Maruki, Y.Okano, N.Todaka, A.Ozaka, M.Tsuji, K.Shioji, K.Doi, K.Kojima, Y.Tsumura, H.Tanaka, K.Higuchi, H.Kawabe, K.Imaoka, H.Yamashita, T.Miwa, H.Nagano, H.Arima, S.Hayashi, H.Naganuma, A.Yamaguchi, H.Hisano, T.Umemoto, K.Ishii, S.Nakashima, K.Suzuki, R.Kitano, Y.Misumi, T.Furuse, J.Ishii, H.

16. Phase I study of envafolimab (KN035), a novel subcutaneous single-domain anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors

• Invest New Drugs,40(5):1021-1031, 2022.
• Shimizu T, Nakajima TE, Yamamoto N, Yonemori K, Koyama T, Kondo S, Sunakawa Y, Izawa N, Horie Y, Xiang S, Xu S, Qin L, Gong J, Liu D.

17. Nivolumab for treating patients with occupational cholangiocarcinoma

• J Hepatobiliary Pancreat Sci.,29(11):1153-1155, 2022.
• Shogo Tanaka, Kumiko Umemoto, Shoji Kubo, Yasunori Sato, Sachiyo Mimaki, Katsuya Tsuchihara, Shigekazu Takemura, Hiroji Shinkawa, Akira Mori, Masafumi Ikeda.

18. Feasibility of edoxaban for asymptomatic cancer-associated thrombosis in Japanese patients with gastrointestinal cancer: ExCAVE study

• BMC cancer.,22(1):1322-1322, 2022.
• Nakamura M, Ishiguro A, Dazai M, Kawamoto Y, Yuki S, Sogabe S, Hosokawa A, Sawada K, Muto O, Izawa N, Nakashima K, Horie Y, Yagisawa M, Kajiura S, Ando T, Mitsuhashi Y, Sunakawa Y, Kikuchi Y, Komatsu Y.

19. Efficacy of chemotherapy for patients with metastatic or recurrent pancreatic adenosquamous carcinoma: A multicenter retrospective analysis

• Pancreatology, 22(8):1159-1166, 2022.
• Yoshida, Y.Kobayashi, S.Ueno, M.Morizane, C.Tsuji, K.Maruki, Y.Mori, K.Watanabe, K.Ohba, A.Furuta, M.Todaka, A.Tsujimoto, A.Ozaka, M.Okano, N.Yane, K.Umemoto, K.Kawamoto, Y.Terashima, T.Tsumura, H.Doi, K.Shioji, K.Asagi, A.Kojima, Y.Suzuki, E.Toshiyama, R.Furukawa, M.Naganuma, A.Suzuki, R.Miwa, H.Ikeda, M.Furuse, J.

20. Comprehensive clinical and molecular characterization of claudin 18.2 expression in advanced gastric or gastroesophageal junction cancer

• ESMO Open, 8(1):100762, 2022.
• Y.Kubota, A.Kawazoe, S.Mishima, Y.Nakamura, D.Kotani, Y.Kuboki, H.Bando, T.Kojima, T.Doi, T.Yoshino, T.Kuwata, K.Shitara

21. Clinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer

• British Journal of Cancer, 128:1603-1608, 2022.
• Umemoto K, Sunakawa Y, Ueno M, Furukawa M, Mizuno N, Sudo K, Kawamoto Y, Kajiwara T, Ohtsubo K, Okano N, Matsuhashi N, Itoh S, Matsumoto T, Shimizu, S, Otsuru T, Hasegawa H, Okuyama H, Ohama H, Moriwaki T, Ohta T, Odegaard J. I, Nakamura Y, Bando H, Yoshino T, Ikeda M, Morizane C.

22. Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study

• The Lancet Oncology, 24(2):151-161, 2022.
• Wang J, Xiu J, Farrell A, Baca Y, Arai H, Battaglin F, Kawanishi N, Soni S, Zhang W, Millstein J, Shields AF, Grothey A, Weinberg BA, Marshall JL, Lou E, Khushman M, Sohal DPS, Hall MJ, Liu T, Oberley M, Spetzler D, Korn WM, Shen L, Lenz HJ.

23. Impact of genetic variants involved in the lipid metabolism pathway on progression free survival in patients receiving bevacizumab-based chemotherapy in metastatic colorectal cancer: a retrospective analysis of FIRE-3 and MAVERICC trials.

• eClinicalMedicine, 57:101827, 2022.
• Wang J, Millstein J, Yang Y, Stintzing S, Arai H, Battaglin F, Kawanishi N, Soni S, Zhang W, Mancao C, Cremolini C, Liu T, Heinemann V, Falcone A, Shen L, Lenz HJ.

24. Phase I study of aflibercept in combination with docetaxel in Japanese patients with advanced solid malignancies.

• Invest New Drugs, 40(5):1032-1041.
• Sunakawa Y, Takahashi K, Kawaguchi O, Yamamoto N.

25. Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer.

• N Engl J Med, 388(1):33-43.
• Strickler JH, Satake H, George TJ, Yaeger R, Hollebecque A, Garrido-Laguna I, Schuler M, Burns TF, Coveler AL, Falchook GS, Vincent M, Sunakawa Y, Dahan L, Bajor D, Rha SY, Lemech C, Juric D, Rehn M, Ngarmchamnanrith G, Jafarinasabian P, Tran Q, Hong DS.

《2021年度》

《原著・総説・解説》

1. An observational study on nutrition status in gastric cancer patients receiving ramucirumab plus taxane: BALAST study.

• Future Oncology, 17(19)：2431-2438, 2021.
• Takuro Mizukami, Tempei Miyaji, Yukiya Narita, Tomohiro Matsushima, Takashi Ogura, Hiromichi Miyagaki, Ryohei Kawabata, Yoshiki Horie, Takashi Kawaguchi, Kei Muro, Hiroki Hara, Takuhiro Yamaguchi& Takako E Nakajima.

2. Germ line polymorphisms of genes involved in pluripotency transcription factors predict efficacy of cetuximab in metastatic colorectal cancer.

• European Journal of Cancer, 150：133-142, 2021.
• Hiroyuki Arai, Joshua Millstein, Fotios Loupakis, Sebastian Stintzing, Jingyuan Wang, rancesca Battaglin, Natsuko Kawanishi, Priya Jayachandran, Shivani Soni, Wu Zhang, Shannon M Mumenthaler, Chiara Cremolini, Volker Heinemann, Alfredo Falcone, Heinz-Josef Lenz.

3. Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cance.

• Clin Cancer Res, 27(20)5619-5627, 2021.
• Tomoko Jogo, Yoshiaki Nakamura, Kohei Shitara, Hideaki Bando, Hisateru Yasui, Taito Esaki, Tetsuji Terazawa, Taroh Satoh, Eiji Shinozaki, Tomohiro Nishina, Yu Sunakawa, Yoshito Komatsu, Hiroki Hara, Eiji Oki, Nobuhisa Matsuhashi, Takashi Ohta, Takeshi Kato, Koushiro Ohtsubo, Takeshi Kawakami, Naohiro Okano, Yoshiyuki Yamamoto, Takanobu Yamada, Akihito Tsuji, Justin I Odegaard, Hiroya Taniguchi, Toshihiko Doi, Satoshi Fujii, Takayuki Yoshino.

4. Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS-MAPK pathway and TP53 as potential predictors of immunotherapy efficacy.

• Annals of Oncology, 32(7):906-916, 2021.
• J Y Wang, J Xiu, Y Baca, H Arai, F Battaglin, N Kawanishi, S Soni, W Zhang, J Millstein, A F Shields, A Grothey, B A Weinberg, J L Marshall, E Lou, M Khushman, D P S Sohal, M J Hall, M Oberley, D Spetzler, L Shen, W M Korn, H J Lenz.

5. Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer.

• Oncogene, 40:4894-4905, 2021.
• Jingyuan Wang, Joanne Xiu, Yasmine Baca, Francesca Battaglin, Hiroyuki Arai, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Bodour Salhia, Richard M Goldberg, Philip A Philip, Andreas Seeber, Jimmy J Hwang, Anthony F Shields, John L Marshall, Igor Astsaturov, A Craig Lockhart, Zoran Gatalica, W Michael Korn, Heinz-Josef Lenz.

6. Real-world effectiveness of nivolumab in advanced gastric cancer: the DELIVER trial (JACCRO GC-08).

• Gastric Cancer, 25(1):235-244, 2021
• Yoshikazu Takahashi, Yu Sunakawa, Eisuke Inoue, Ryohei Kawabata, Atsushi Ishiguro, Yosuke Kito, Yusuke Akamaru, Masazumi Takahashi, Hiroshi Yabusaki, Jin Matsuyama, Akitaka Makiyama, Masahiro Tsuda, Takahisa Suzuki, Hisateru Yasui, Ryo Matoba, Hisato Kawakami, Takako Eguchi Nakajima, Kei Muro, Wataru Ichikawa, Masashi Fujii.

7. Homologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic Implications.

• J Natl Cancer Inst, 114(2):271-279, 2021.
• Roberto Moretto, Andrew Elliott, Jian Zhang, Hiroyuki Arai, Marco Maria Germani, Veronica Conca, Joanne Xiu, Phillip Stafford, Matthew Oberley, Jim Abraham, David Spetzler, Daniele Rossini, Carlotta Antoniotti, John Marshall, Anthony Shields, Gilberto Lopes, Sara Lonardi, Filippo Pietrantonio, Gianluca Tomasello, Alessandro Passardi, Emiliano Tamburini, Daniele Santini, Giuseppe Aprile, Gianluca Masi, Alfredo Falcone, Heinz-Josef Lenz, Michael Korn, Chiara Cremolini.

8. Clinical Significance of Circulating Tumor Cell Induced Epithelial-Mesenchymal Transition in Patients with Metastatic Colorectal Cancer by Single-Cell RNA-Sequencing.

• Cancers (Basel), 13(19):4862, 2021.
• Masahiro Kozuka, Francesca Battaglin, Priya Jayachandran, Jingyuan Wang, Hiroyuki Arai, Shivani Soni, Wu Zhang, Mitsuharu Hirai, Satoshi Matsusaka, Heinz-Josef Lenz.

9. Clinical implications of using both fluoropyrimidine and paclitaxel in patients with severe peritoneal metastasis of gastric cancer: A post hoc study of JCOG1108/WJOG7312G.

• Cancer Medicine, 10(21):7673-7682, 2021.
• Hiroyuki Arai, Eisuke Inoue, Kensei Yamaguchi, Narikazu Boku, Hiroki Hara, Tomohiro Nishina, Masahiro Tsuda, Kohei Shitara, Katsunori Shinozaki, Shinichiro Nakamura, Ichinosuke Hyodo, Kei Muro, Mitsuru Sasako, Masanori Terashima, Takako E Nakajima.

10. Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.

• Br J Cancer.126;72-78, 2021.
• Hiroyuki Arai, Yi Xiao, Joshua Millstein, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Priya Jayachandran, Shivani Soni, Wu Zhang, Christoph Mancao, Bodour Salhia, Shannon M Mumenthaler, Aparna R Parikh, Heinz-Josef Lenz.

11. Role of nutritional care and general guidance for patients with advanced or metastatic gastric cancer.

• Future Oncology, 17(23)：3101-3109, 2021.
• Takuro Mizukami, Yongzhe Piao.

12. The potential targeted drugs for fusion genes including NRG1 in pancreatic cancer.

• Critical Reviews in Oncology/Hematology, 166：103465, 2021.
• Kumiko Umemoto, Yu Sunakawa.

13. Second-line chemotherapy after early disease progression during first-line chemotherapy containing bevacizumab for patients with metastatic colorectal cancer.

• BMC Cancer, 21(1)：1159, 2021.
• Yamamoto S, Nagashima K, Kawakami T, Mitani S, Komoda M, Tsuji Y, Izawa N, Kawakami K, Yamamoto Y, Makiyama A, Yamazaki K, Masuishi T, Esaki T, Nakajima TE, Okuda H, Moriwaki T, Boku N.

14. Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer.

• Springer Nature, 41：260-267, 2021.
• Hiroyuki Arai, Andrew Elliott, Joshua Millstein, Joanne Xiu, Fang-Shu Ou, Federico Innocenti, Jingyuan Wang, Francesca Battaglin, Priya Jayachandran, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Davendra Sohal, Richard M Goldberg, Michael J Hall, Aaron J Scott, Mohd Khushman, Jimmy J Hwang, Emil Lou, Benjamin A Weinberg, Albert Craig Lockhart, Anthony Frank Shields, Jim P Abraham, Daniel Magee, Phillip Stafford, Jian Zhang, Alan P Venook, W Michael Korn, Heinz-Josef Lenz.

15. Clinical Validity of Plasma-Based Genotyping for Microsatellite Instability Assessment in Advanced GI Cancers: SCRUM-Japan GOZILA Substudy.

• JCO Precis Oncol, e2100383, 2022.
• Nakamura Y, Okamoto W, Denda T, Nishina T, Komatsu Y, Yuki S, Yasui H, Esaki T, Sunakawa Y, Ueno M, Shinozaki E, Matsuhashi N, Ohta T, Kato K, Ohtsubo K, Bando H, Hara H, Satoh T, Yamazaki K, Yamamoto Y, Okano N, Terazawa T, Kato T, Oki E, Tsuji A, Horita Y, Hamamoto Y, Kawazoe A, Nakajima H, Nomura S, Mitani R, Yuasa M, Akagi K, Yoshino T.

16. The clinical utility of comprehensive measurement of autoimmune disease-related antibodies in patients with advanced solid tumors receiving immune checkpoint inhibitors: a retrospective study.

• ESMO Open, 7(2):100415, 2022.
• N Izawa, H Shiokawa, R Onuki, K Hamaji, K Morikawa, H Saji, H Ohashi, S Kasugai, N Hayakawa, T Ohara, Y Sunakawa.

17. A phase II multicenter trial assessing the efficacy and safety of first-line S-1 + ramucirumab in elderly patients with advanced/recurrent gastric cancer: KSCC1701.

• Eur J Cancer, 166:279-286, 2022.
• Kazuma Kobayshi, Koichi Suyama, Hiroo Katsuya, Naoki Izawa, Yoshikazu Uenosono, Qingjiang Hu, Tetsuya Kusumoto, Hajime Otsu, Hiroyuki Orita, Hirofumi Kawanaka, Kazunori Shibao, Satoshi Koga, Mototsugu Shimokawa, Akitaka Makiyama, Hiroshi Saeki, Eiji Oki, Hideo Baba, Masaki Mori.

18. Clinical Utility of Genomic Profiling Tests in Patients with Advanced Gastrointestinal Cancers.

• Targeted Oncology, 17:177–185, 2022.
• Hiroyuki Takeda, Kiyomi Imoto, Kumiko Umemoto, Ayako Doi, Hiroyuki Arai, Yoshiki Horie, Takuro Mizukami, Tomoyo Oguri, Takashi Ogura, Naoki Izawa, Hiroyuki Yamamoto, Yoshihisa Yamano & Yu Sunakawa.

19. Impact of Body Weight Loss on Survival in Patients with Advanced Gastric Cancer Receiving Second-Line Treatment.

• Nutr Cancer, 74(2):539-545, 2022.
• Mizukami T, Hamaji K, Onuki R, Yokomizo A, Nagashima Y, Takeda H, Umemoto K, Doi A, Arai H, Hirakawa M, Horie Y, Izawa N, Ogura T, Tsuda T, Sunakawa Y, Shibata M, Tanaka T, Mikami S, Nakajima TE.

《症例報告》

1. Detection of a pinhole-sized bronchoesophageal fistula under bronchoscopic autofluorescence imaging.

• Thoracic Cancer, 12(13)：2043-2045, 2021.
• Kei Morikawa, Naoki Izawa, Hirotaka Kida, Hiroshi Handa, Takeo Inoue, Masamichi ineshita.

2. REMARRY and PURSUIT trials: liquid biopsy-guided rechallenge with anti-epidermal growth factor receptor (EGFR) therapy with panitumumab plus irinotecan for patients with plasma RAS wild-type metastatic colorectal cancer.

• BMC Cancer, 21(1)：674, 2021.
• Nakajima H, Kotani D, Bando H, Kato T, Oki E, Shinozaki E, Sunakawa Y, Yamazaki K, Yuki S, Nakamura Y, Yamanaka T, Yoshino T, Ohta T, Taniguchi H, Kagawa Y.

臨床腫瘍学業績 2014年度～2020年度

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